Martin-Luther-Universität Halle-Wittenberg
Forschungsbericht Berichtszeitraum:01.01.99 - 31.12.00

Medizinische Fakultät

Institut für Pharmakologie und Toxikologie

Institut für Pharmakologie und Toxikologie (ohne Sektionen)

Veröffentlichungen

Herausgeberschaften 1999 :

 

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Herausgeberschaften 2000 :

 

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Monographien 1999 :

 

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Monographien 2000 :

 

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Buchbeiträge 1999 :

 

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Buchbeiträge 2000 :

 

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Artikel in Zeitschriften 1999 :

 

17

Artikel in Zeitschriften 2000 :

 

11

 

 

 

Artikel in Konferenzbänden 1999 :

 

27

Artikel in Konferenzbänden 2000 :

 

22

 

 

 

Artikel in Zeitschriften 1999

     

  1. Schäfers RF, Karl I, Mennicke K, Daul AE, Philipp T, Brodde O-E. Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers. Br J Clin Pharmacol 47: 59-66, 1999.

    2.  

  2. Jakubetz J, Schmuck S, Poller U, Fuchs B, Gorf A, Radke J, Pönicke K, Brodde O-E. Cardiac effects of b -adrenoceptor antagonists with intrinsic sympathomimetic activity in humans: b 1- and/or b 2-adrenoceptor mediated? J Cardiovasc Pharmacol 33: 461-472, 1999.

    3.  

  3. De Vries RJM, Brodde O-E, Van Veldhuisen DJ, Anthonio RL, Buikema H, Scholtens E, Van Gilst WH. Effects of amlodipine on autonomic parameters in a rat model of experimental myocardial infarction and left ventricular dysfunction. Cardiologie 6: 248-253, 1999

    4.  

  4. Schäfers RF, Piest U, von Birgelen C, Jakubetz J, Daul AE, Philipp T, Brodde O-E. Disodium cromoglycate does not prevent terbutaline-induced desensitization of b 2-adrenoceptor-mediated cardiovascular in vivo functions in human volunteers. J Cardiovasc Pharmacol 33: 822-827, 1999.

    5.  

  5. Giessler C, Dhein S, Pönicke K, Brodde O-E. Muscarinic receptors in the failing human heart. (Invited Review) Eur J Pharmacol 375: 197-202, 1999.

    6.  

  6. Pönicke K, Heinroth-Hoffmann I, Becker K, Osten B, Brodde O-E. Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: role of Gi-proteins and protein kinase C. Naunyn-Schmiedeberg's Arch Pharmacol 360: 301-308, 1999.

    7.  

  7. Michel MC, Plogmann, C, Philipp T, Brodde O-E. Functional correlates of a 2A-adrenoceptor gene polymorphism in the HANE study. Nephrol Dial Transplant 14:2657-2663, 1999.

    8.  

  8. Brodde O-E, Michel MC. Adrenergic and muscarinic receptors in the human heart. (Invited Review). Pharmacol Rev 51: 651-689, 1999.

    9.  

  9. Dhein S, Krüsemann K, Schaefer T. Effects of the gap junction uncoupler palmitoleic acid on the activation and repolarization pattern in isolated rabbit hearts. A mapping study. Br J Pharmacol 128: 1375-1384, 1999.

    10.  

  10. Olbrich A, Salameh A, Rösen P, Dhein S. Different effects of the b -adrenoceptor antagonists celiprolol and metoprolol on vascular structure and function in long-term type I diabetes mellitus in rats. J Cardiovasc Pharmacol 33: 193-203, 1999.

    11.  

  11. Mehlhorn U, Sauer H, Kuhn-Regnier F, Südkamp M, Dhein S, Eberhardt F, Grond S, Hekmat K, Horst M, Geissler HJ, Warters RD, Allen SJ, deVivie ER. Myocardial b -blockade as an alternative to cardioplegic arrest coronary artery surgery. Cardiovasc Surg 7: 549-557, 1999.

    12.  

  12. Müller A, Lauven M, Berkels R, Dhein S, Polder HR, Klaus W. Switched single electrode voltage clamp amplifiers allow precise measurement of gap junction conductance. Am J Physiol 276: C980-C987, 1999.

    13.  

  13. Dhein S, Salameh A, Berkels R, Klaus W. Dual mode of action of 1,4-dihydropyridines. A role for nitric oxide. Drugs 58: 397-404, 1999.

    14.  

  14. Kuhn-Reigner F, Natour E, Sauer H, Engelmann F, Dhein S, Geissler HJ, Larose K, Görg C, Dapunt O, Devivie ER: Beta-blockade versus Buckberg blood cardioplegia in coronary bypass operation. Eur J Cardiothoracic Surg 15: 67-74, 1999.

    15.  

  15. Dapunt OE, Raji MR, Jeschkeit S, Dhein S, Kuhn-Reignier F, Südkamp M, Fischer JH, Mehlhorn U. Intracoronary shunt insertion prevents myocardial stunning in a juvenile porcine MIDCAB model absent of coronary artery disease. Eur J Cardiothorac Surg 15: 173-178, 1999.

    16.  

  16. Dhein S, Salameh A. Letter to the editor: Amlodipine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel-blocking agent. Circulation 100: 1011, 1999.

    17.  

  17. Dhein S, Salameh A: Na+/H+-exchange inhibition by cariporide (Hoe 642): a new principle in cardiovascular medicine. Cardiovasc Drug Rev 17: 134-146, 1999.

 

Artikel in Zeitschriften 2000

     

  1. Anthonio RL, Brodde O-E, Van Veldhuisen DJ, Scholtens E, Crijns HJGM, Van Gilst WH. b-Adrenoceptor density in chronic infarcted myocardium: a subtype specific decrease of b1-adrenoceptor density. Int J Cardiol 72 (2000) 137-142.

    2.  

  2. Pönicke K, Giessler C, Grapow M, Heinroth-Hoffmann I, Becker K, Osten B, Brodde O-E. FP-receptor mediated trophic effects of prostanoids in rat ventricular cardiomyocytes. Br J Pharmacol 129 (2000) 1723-1731.

    3.  

  3. Jakubetz J, Schmuck S, Wochatz G, Ruhland B, Poller U, Radke J, Brodde O-E. Human cardiac b1- or b2-adrenoceptor stimulation and the negative chronotropic effect of low dose pirenzepine. Clin Pharmacol Ther 67 (2000) 549-57.

    4.  

  4. Dhein S, Röhnert P, Markau S, Kotchi-Kotchi E, Becker K, Poller U, Osten B, Brodde O-E. Cardiac b -adrenoceptors in chronic uremia. Studies in humans and rats. J Am Coll Cardiol 36 (2000) 608-617.

    5.  

  5. Dhein S, Giessler C, Wangemann T, Silber R-E, Zerkowski H-R, Brodde O-E. Differential pattern of endothelin-1-induced inotropic effects in right atria and left ventricles of the human heart. J Cardiovasc Pharmacol 36 (2000) 564-569.

    6.  

  6. Seyfarth T, Gerbershagen H-P, Giessler C, Leineweber K, Heinroth-Hoffmann I, Pönicke K, Brodde O-E. The cardiac b-adrenoceptor-G-protein(s)-adenylyl cylcase system in monocrotaline-treated rats. J Mol Cell Cardiol 32: 2315-2326, 2000.

    7.  

  7. Leineweber K, Seyfarth T, Brodde O-E. Chamber-specific alterations of noradrenaline uptake (uptake1) in right ventricles of monocrotaline-treated rats. Br J Pharmacol 131: 1438-1444, 2000.

    8.  

  8. Dhein S, Hochreuther S, aus dem Spring C, Bollig K, Hufnagel C, Raschack M. Long term effects of endothelin A receptor antagonist LU 135252 and the ACE inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type I diabetes mellitus rat model. J Pharmacol Exp Ther 293: 351-359, 2000.

    9.  

  9. Dhein S. Arzneimittel-bedingte QT-Prolongation und Torsade de Pointes Arrhytmien. Dtsch Med Wschr 125:703-708, 2000.

    10.  

  10. Dhein S, Pejman P, Krüsemann K. Effects of the IK.ATP-blockers glibenclamide and HMR 1883 on cardiac electrophysiology during regional ischemia and reperfusion. Eur J Pharmacol 398: 273-284, 2000.

    11.  

  11. Eberhardt F, Mehlhorn U, Sauer H, LaRosee K, de Vivie ER, Dhein S. Structural myocardial changes after coronary artery surgery. Eur J Clin Invest 30: 938-946, 2000.

Artikel in Konferenzbänden 1999

     

  1. Pönicke K, Heinroth-Hoffmann I, Agambai D, Brodde O-E. Effects of prostanoids on inositol phosphate formation and protein synthesis in rat neonatal ventricular cardiomyocytes. Br J Pharmacol 126 (Suppl): 212P, 1999.

    2.  

  2. Pönicke K, Heinroth-Hoffmann I, Agambai D, Becker K, Brodde O-E. Effects of prostanoids on inositol phosphate formation and rate of protein synthesis in rat neonatal ventricular cardiomyocytes. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R132, 1999.

    3.  

  3. Kotchi-Kotchi E, Grapow M, Heinroth-Hoffmann I, Brodde O-E. The impaired negative inotropic effect of nitric oxide in cardiac hypertrophy depends on guanylate cyclase. Naunyn Schmiedebergs’s Arch Pharmacol 359 (Suppl): R402, 1999.

    4.  

  4. Heinroth-Hoffmann I, Schiewe P, Struppert A, Hauser A, Brodde O-E. Endothelin- and noradrenalin-induced inositol phosphate formation in ventricular cardiomyocytes from aortic banded rats. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R415, 1999.

    5.  

  5. Giessler C, Becker K, Heinroth-Hoffmann I, Brodde O-E. Endothelin-1 effects in isolated Langendorff-perfused hearts and aorta in two rat models of cardiac hypertrophy. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R427, 1999.

    6.  

  6. Schmuck S, Wöllenweber F, Jakubetz J, Poller U, Radke J, Brodde O-E. Influence of bisoprolol on dopamine-induced hemodynamic effects in healthy volunteers. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R474, 1999.

    7.  

  7. Jakubetz J, Schmuck S, Poller U, Radke J, Brodde O-E. The intrinsic sympathomimetic activity of carteolol in humans is mediated by b2-adrenoceptor activation. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R496, 1999.

    8.  

  8. Brodde O-E, Becker K, Silber R-E, Zerkowski H-R. Cardiac muscarinic receptors in the ageing and failing human heart. FASEB J 13: A111, 1999.

    9.  

  9. Pönicke K, Heinroth-Hoffmann I, Brodde O-E. Propranolol increases noradrenaline-induced protein synthesis in ventricular cardiomyocytes of the adult rat. Br J Pharmacol 128 (Suppl): 58P, 1999.

    10.  

  10. Grapow M, Seyfarth T, Dhein S, Brodde O-E. Comparison of the effects of endothelin-1 on force of contraction in right and left ventricles of the rat heart. Br J Pharmacol 128 (Suppl): 59P, 1999.

    11.  

  11. Brodde O-E, Giessler C, Silber R-E, Zerkowski H-R. Human cardiac muscarinic receptors are differentially altered with age or in chronic heart failure. Circulation 100 (Suppl): I-508, 1999.

    12.  

  12. Markau S, Osten B, Lohmann SM, Gambaryan S, Brodde O-E. Reduced cardiac NO/cGMP-system in experimental uremia. J Am Soc Nephrol 10: A3367, 1999.

    13.  

  13. Schmuck S, Poller U, Jakubetz J, Radke, J, Nguyen T, Brodde O-E. The intrinsic sympathomimetic activity of the b-adrenoceptor antagonist cateolol is b2-adrenoceptor mediated. Br J Clin Pharmacol 48: 875P-876P, 1999.

    14.  

  14. Dhein S, Krüsemann K, Pejman P. Effects of the IK.ATP blockers glibenclamide and HMR1883 on cardiac electrophysiology during regional ischaemia and reperfusion. Br J Pharmacol 126 (Suppl): 37P, 1999.

    15.  

  15. Salameh A, Dhein S, Beuckelmann DJ. Effects of cariporide (Hoe 642) on intracellular calcium homeostasis during acidosis in cardiomyocytes. Br J Pharmacol 126 (Suppl): 114P, 1999.

    16.  

  16. Dhein S, Schaefer T, Poeppel P, Grover R, Bachmann M, Müller A. On the molecular mechanism of action of antiarrhythmic peptides in transfected HeLa-Cx43-cells. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R7, 1999.

    17.  

  17. Lauven M, Müller A, Klaus W, Dhein S. The antiarrhythmic peptide AAP10 increases gap junctional conductance but decreases dye transfer in connexin 43-transfected HeLa-cells. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R108, 1999.

    18.  

  18. Krüsemann K, Dhein S. Differential effects of the IK.ATP.blockers glibenclamide and HMR1883 on cardiac electrophysiology in ischemic and non-ischemic tissue. A mapping study. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R111, 1999.

    19.  

  19. Eberhardt F, Mehlhorn U, Sauer H, DeVivie ER, Dhein S. Myocardial stunning during aortocoronary bypass grafting (ACGB). Effects of esmolol. Naunyn Schmiedeberg’s Arch Pharmacol 359 (Suppl): R122, 1999.

    20.  

  20. Dhein S, Krüsemann K, Schaefer T. Effects of the gap junction uncoupler palmitoleic acid on activation and repolarization patterns in isolated hearts. Eur J Physiol 437 (Suppl): R156, 1999.

    21.  

  21. Dhein S, Grover R, Müller A, Lauven M, Poeppel P, Schaefer T. Enhancement of cardiac gap junction conduction: new aspects of the molecular mechanism of action of antiarrhythmic peptides. Circulation 100 (Suppl I): I-426, 1999.

    22.  

  22. Dhein S, Hochreuther S, Hufnagel C, Raschack M. Effects of the ETA-receptor antagonist LU135252 and of trandolapril on diabetic angiopathy and nephropathy in a long-term type I diabetes mellitus rat model. Circulation 100 (Suppl I): I-830, 1999.

    23.  

  23. Schaefer T, Gottwald M, Grover R, Dhein S. Action and mechanism of antiarrhythmic peptide AAP10. Eur J Physiol 437 (Suppl): R156, 1999.

    24.  

  24. Kabat A, Dhein S. Chronic treatment with acetylsalicylic acid attenuates endothelial dysfunction induced by high D-Glucose concentrations in porcine aortic endothelial cells. Br J Pharmacol 128 (Suppl): 50P, 1999.

    25.  

  25. Markau S, Deuber HJ, Röhnert P, Becker K, Brodde O-E, Osten B. Cardiac and vascular endothelin receptors in experimental chronic uremia. Kidney & Blood Pressure Research 22: 265, 1999.

    26.  

  26. Markau S, Poller U, Röhnert P, Preiss M, Kotchi-Kotchi E, Deuber HJ, Osten B, Brodde O-E. Decreased cardiac-adrenoceptor function in chronic uremia. Blood Purification 17: 222, 1999.

    27.  

  27. Markau S, Poller U, Röhnert P, Preiss, Kotchi-Kotchi E, Deuber HJ, Osten B, Brodde O-E. Cardiac ß-Adrenoceptor function in chronic uremia. Vienna, Nov. 1999, 20-23.

 

Artikel in Konferenzbänden 2000

     

  1. Seyfarth T, Heinroth-Hoffmann I, Gerbershagen H-P, Pönicke K, Brodde O-E. Right ventricular b -adrenoceptors in monocrotaline-treated rats. Br J Pharmacol 129 (Suppl): 185 P, 2000.

    2.  

  2. Becker K, Giessler C, Pönicke K, Brodde O-E. Inositol phosphate formation in rat thoracic and abdominal aorta. Br J Pharmacol 129 (Suppl): 209 P, 2000.

    3.  

  3. Schmuck S, Jakubetz J, Wochatz G, Ruhland B, Radke J, Brodde O-E. The negative chronotropic effect of pirenzepine does not differentiate between b 1- and b 2-adrenoceptor stimulation. Br J Clin Pharmacol 49: 497 P, 2000.

    4.  

  4. Pönicke K, Beilfuß A, Niebisch M, Hauser A, Adler I, Brodde O-E. Noradrenaline-induced hypertrophic response in adult rat ventricular cardiomyocytes is mediated by a 1A-adrenoceptor stimulation. Naunyn Schmiedeberg’s Arch Pharmacol 361(Suppl): R95, 2000.

    5.  

  5. Becker K, Heinroth-Hoffmann I, Giessler C, Brodde O-E. Ontogenetic changes of Gq/11-coupled receptor function in heart and kidney in two rat models of left ventricular hypertrophy. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R428, 2000.

    6.  

  6. Seyfarth T, Giessler C, Gerbershagen H-P, Heinroth-Hoffmann I, Brodde O-E. Cardiac b-adrenoceptors in monocrotaline-treated rat. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R111, 2000.

    7.  

  7. Heinroth-Hoffmann I, Becker K, Brodde O-E. Are changes of endothelin-1 responses in heart hypertrophy dependent on high blood pressure? Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R442, 2000.

    8.  

  8. Leineweber K, Seyfarth T, Brodde O-E. Chamber-specific alterations of noradrenaline transporter activity and binding sites in monocrotaline-treated rats with experimental right-heart failure. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R114, 2000.

    9.  

  9. Giessler C, Becker K, Brodde O-E. Differential effects of endothelin-1, U46619 and noradrenaline in aorta thoracica and abdominalis of rat. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R454, 2000.

    10.  

  10. Tellkamp R, Schmuck S, Radke J, Brodde O-E. Sex-specific differences in the functional responsiveness of human b2-adrenoceptors: an in vivo study in healthy volunteers. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R128, 2000.

    11.  

  11. Markau S, Becker K, Röhnert P, Brodde O-E, Osten B. Relation between ET-receptor function and blood pressure: studies in SHR, aortic banded and chronic uremic rats. J Am Soc Nephrol 11: 337A, 2000.

    12.  

  12. Kabat A, Salameh A, Dhein S. Effect of a b2.adrenoceptor stimulation on hyperglycaemia-induced endothelial dysfunction. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R48, 2000.

    13.  

  13. Dhein S, Hammerath SB. Effect of a gap junction blockade using palmitoleic acid in the beating heart. Anisotropy and electrophysiology. Naunyn Schmiedeberg’s Arch Pharmacol 361 (Suppl): R108, 2000.

    14.  

  14. Werner C, Werdan K, Brodde O-E, Loppnow H. Die erhöhte TNF-Rezeptor- und IL-10-Konzentrationen in CHF-Patienten sind in Metoprolol-behandelten Patienten reduziert. Z Kardiol 2000.

    15.  

  15. Brodde O-E, Giessler C, Becker K, Silber R-E, Zerkowski H-R. Muskarin-Rezeptoren im alten und im kranken menschlichen Herzen. Z Kardiol 2000.

    16.  

  16. Büscher R, Eilmes KJ, Schmuck S, Tellkamp R, Insel PA, Hoyer PF, Brodde O-E. b2-adrenergic receptor polymorphisms at codon 27: cardiovascular phenotypes in healthy caucasians. FASEB J14: A1346, 2000.

    17.  

  17. Leineweber K, Seyfarth T, Pönicke K, Brodde O-E. Noradrenaline uptake decreased in right but not left ventricles of monocrotaline-treated rats. FASEB J 14: A1412, 2000.

    18.  

  18. Pönicke K, Seyfarth T, Schlüter K-D, Brodde O-E. Noradrenaline-induced hypertrophic response in adult rat ventricular cardiomyocytes is mediated by alpha-1A adrenergic receptors. FASEB J 14: A 1413, 2000.

    19.  

  19. Becker K, Heinroth-Hoffmann I, Pönicke K, Brodde O-E. Endothelin-receptor function in relation to blood pressure on spontaneously hypertensive and aortic-banded rats. Circulation 102 (Suppl. II): II-95, 2000.

    20.  

  20. Goldberg M, Pönicke K, Schlüter K-D, Brodde O-E. Signalling pathway of a1-adrenoceptor-mediated hypertrophic response in adult rat cardiomyocytes: involvement of only a1A-adrenoceptors. Circulation 102 (Suppl. II): II-102, 2000.

    21.  

  21. Markau S, Becker K, Giessler C, Heinroth-Hoffmann I, Kresse S, Osten B, Brodde O-E. Änderungen des Blutdrucks und Funktion vaskulärer ET-Rezeptoren. Nieren-u. Hochdruckkrankheiten 29: 356, 2000.

    22.  

  22. Markau S, Becker K, Giessler C, Heinroth-Hoffmann I, Kresse S, Osten B, Brodde O-E. Blood Pressure Changes and Vascular ET-Receptor Function. Kidney Blood Press Res 23: 249, 2000.

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